Issue 54, 2024

Evolution in the asymmetric synthesis of biaryl ethers and related atropisomers

Abstract

Axially chiral biaryl ethers and related compounds hold valuable potential in natural products, medicinal chemistry, and catalysis; however, their asymmetric syntheses have always been overlooked compared to other biaryl/hetero-biaryl atropisomers. Unlike the later class molecules bearing a single chiral axis, the former category possesses a unique type of atropisomerism bearing two potential axes. Due to their great importance in diverse research domains, catalytic atropselective biaryl ether synthesis has recently witnessed an upsurge. This highlight article provides an elaborated view on the developments of catalytic synthetic methods that have been explored to achieve dual axial chirality in biaryl ethers and related scaffolds.

Graphical abstract: Evolution in the asymmetric synthesis of biaryl ethers and related atropisomers

Article information

Article type
Highlight
Submitted
09 Apr 2024
Accepted
14 May 2024
First published
14 May 2024

Chem. Commun., 2024,60, 6837-6846

Evolution in the asymmetric synthesis of biaryl ethers and related atropisomers

N. Kotwal and P. Chauhan, Chem. Commun., 2024, 60, 6837 DOI: 10.1039/D4CC01655F

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