Issue 52, 2024

Optimization of boronic ester-based amphiphilic copolymers for ROS-responsive drug delivery

Abstract

This study introduces boronic ester-based ROS-responsive amphiphilic copolymers for antioxidant drug delivery. Tuning the hydrophobic/hydrophilic balance optimized the size, curcumin encapsulation, ROS-triggered release, cellular uptake, and intracellular ROS scavenging. The lead P1b formulation self-assembled into stable 10 nm micelles enabling rapid ROS-triggered curcumin release and preferential cellular internalization. P1b eliminated over 90% of pathogenic intracellular ROS within 10 minutes, demonstrating a rapid antioxidant therapy.

Graphical abstract: Optimization of boronic ester-based amphiphilic copolymers for ROS-responsive drug delivery

Supplementary files

Article information

Article type
Communication
Submitted
18 Apr 2024
Accepted
03 Jun 2024
First published
04 Jun 2024

Chem. Commun., 2024,60, 6683-6686

Optimization of boronic ester-based amphiphilic copolymers for ROS-responsive drug delivery

Y. Gao, R. Yang, Z. Shou, X. Zan and S. Tang, Chem. Commun., 2024, 60, 6683 DOI: 10.1039/D4CC01836B

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