Issue 65, 2024

N-Alkylation of amines with primary/secondary alcohols using a novel cobalt(ii) inverse triazolyl-pyridine complex

Abstract

Herein, we report a highly effective homogeneous methodology for the N-alkylation of amines with primary and secondary alcohols using a Co(II)-complex of an inverse triazolyl-pyridine ligand. The developed methodology tolerates various functional groups to produce the desired N-alkylated products in up to 98% yield. A number of control experiments establish that the developed methodology follows a hydrogen auto-transfer (HAT) pathway.

Graphical abstract: N-Alkylation of amines with primary/secondary alcohols using a novel cobalt(ii) inverse triazolyl-pyridine complex

Supplementary files

Article information

Article type
Communication
Submitted
29 Apr 2024
Accepted
08 Jul 2024
First published
09 Jul 2024

Chem. Commun., 2024,60, 8581-8584

N-Alkylation of amines with primary/secondary alcohols using a novel cobalt(II) inverse triazolyl-pyridine complex

B. Shekhawat, P. S. Gahlaut, D. Gautam and B. Jana, Chem. Commun., 2024, 60, 8581 DOI: 10.1039/D4CC01996B

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