N-Alkylation of amines with primary/secondary alcohols using a novel cobalt(ii) inverse triazolyl-pyridine complex

Abstract

Herein, we report a highly effective homogeneous methodology for the N-alkylation of amines with primary and secondary alcohols using a Co(II)-complex of an inverse triazolyl-pyridine ligand. The developed methodology tolerates various functional groups to produce the desired N-alkylated products in up to 98% yield. A number of control experiments establish that the developed methodology follows a hydrogen auto-transfer (HAT) pathway.