Issue 70, 2024
From the journal:

Chemical Communications

Construction of ligand-binding controlled hemoprotein assemblies utilizing 3D domain swapping†

Tsuyoshi Mashima, ORCID logo *ab   Masaru Yamanaka,a   Atsuki Yoshida,a   Naoya Kobayashi,a   Yui Kanaoka,c   Takayuki Uchihashi ORCID logo cd  and  Shun Hirota ORCID logo *a  

* Corresponding authors

a Division of Materials Science, Graduate School of Science and Technology, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara 630-0192, Japan
E-mail: t.mashima@ms.naist.jp, hirota@ms.naist.jp

b Medilux Research Center, Graduate School of Science and Technology, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara 630-0192, Japan

c Department of Physics, Nagoya University, Nagoya, Japan

d Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences, Higashiyama 5-1, Myodaiji, Okazaki, Japan

Abstract

Association-controllable hemoprotein assemblies were constructed from a fusion protein containing two c-type cytochrome units using 3D domain swapping. The hemoprotein assembly exhibited a dynamic exchange between cyclic and linear structures and could be regulated by carbon monoxide (CO) and imidazole binding.

Graphical abstract: Construction of ligand-binding controlled hemoprotein assemblies utilizing 3D domain swapping

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Article information

DOI
https://doi.org/10.1039/D4CC03129F
Article type
Communication
Submitted
26 Jun 2024
Accepted
06 Aug 2024
First published
07 Aug 2024

Chem. Commun., 2024,60, 9440-9443

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Construction of ligand-binding controlled hemoprotein assemblies utilizing 3D domain swapping

T. Mashima, M. Yamanaka, A. Yoshida, N. Kobayashi, Y. Kanaoka, T. Uchihashi and S. Hirota, Chem. Commun., 2024, 60, 9440 DOI: 10.1039/D4CC03129F

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