Issue 76, 2024

Rh(iii)-catalyzed aldehydic and aryl C–H alkylation with cyclopropanols via C–H/C–C bond activation

Abstract

Herein, we report Rh(III) catalyzed aldehydic or aryl C–H alkylation via C–C bond activation of cyclopropanols, facilitating the synthesis of β-functionalized ketones. The protocol employs cyclopropanol as the alkylating agent with 2-aminobenzaldehyde or aniline derivatives to access a variety of unsymmetrical 1,4-diketones or β-aryl ketones, respectively. The practicality of these transformations is showcased through the modification of natural products, gram-scale synthesis, broad substrate scope and postfunctionalizations.

Graphical abstract: Rh(iii)-catalyzed aldehydic and aryl C–H alkylation with cyclopropanols via C–H/C–C bond activation

Supplementary files

Article information

Article type
Communication
Submitted
28 Jul 2024
Accepted
28 Aug 2024
First published
29 Aug 2024

Chem. Commun., 2024,60, 10576-10579

Rh(III)-catalyzed aldehydic and aryl C–H alkylation with cyclopropanols via C–H/C–C bond activation

O. P. Dash, D. Garg and C. M. R. Volla, Chem. Commun., 2024, 60, 10576 DOI: 10.1039/D4CC03797A

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