Iridium/chiral phosphoramidite–olefin complex-catalysed enantioselective [3+2] annulation of ortho-ketoarylboron compounds with conjugated dienes

Abstract

The iridium-catalysed enantioselective [3+2] annulation of ortho-ketoarylboron compounds with conjugated dienes proceeded to give chiral indanol derivatives bearing an all-carbon quaternary stereogenic center in high yields with high enantioselectivity. Chiral phosphoramidite–olefin ligands were effective for the high reactivity and enantioselectivity.