Issue 92, 2024
From the journal:

Chemical Communications

Topology-selective photo-crosslinking of G-quadruplexes via dual G-quartet and groove recognition†

Ryo Ishikawa,‡a   Kazuki Yanagita,‡a   Sayuri Shimada,a   Shogo Sasaki,b   Takatsugu Hirokawa,cd   Yue Ma,e   Kazuo Nagasawa*a  and  Masayuki Tera ORCID logo *a  

* Corresponding authors

a Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei city, Japan
E-mail: tera@go.tuat.ac.jp, knaga@go.tuat.ac.jp

b Department of Chemistry, Biology, and Environmental Science, Faculty of Science, Nara Women's University, Kitauoyanishi-machi, Nara 630-8506, Japan

c Transborder Medical Research Center, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, Japan

d Division of Biomedical Science, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, Japan

e Bioscience Center, Institute of Science Tokyo, 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan

Abstract

The novel photo-crosslinking ligand 6OTD-Bp, bearing an alkylamine benzophenone (Bp) with macrocyclic hexaoxazole (6OTD), was shown to preferentially ligate with hybrid G4s through recognizing both G-quartets and their characteristic wide groove. Higher crosslinking yield was observed for hybrid G4 with wider grooves.

Graphical abstract: Topology-selective photo-crosslinking of G-quadruplexes via dual G-quartet and groove recognition

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Article information

DOI
https://doi.org/10.1039/D4CC04804K
Article type
Communication
Submitted
17 Sep 2024
Accepted
22 Oct 2024
First published
22 Oct 2024

Chem. Commun., 2024,60, 13550-13553

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Topology-selective photo-crosslinking of G-quadruplexes via dual G-quartet and groove recognition

R. Ishikawa, K. Yanagita, S. Shimada, S. Sasaki, T. Hirokawa, Y. Ma, K. Nagasawa and M. Tera, Chem. Commun., 2024, 60, 13550 DOI: 10.1039/D4CC04804K

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