A water-soluble Gd(III)-based fluorescence/T1-MR dual-modality probe for H2S sensing

Ho-Nam Mak; Xuanyi Lu; Siyu Pan; Yanjuan Gu; Lijun Jiang; Wing-Tak Wong

doi:10.1039/D4CC05042H

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

A water-soluble Gd(iii)-based fluorescence/T₁-MR dual-modality probe for H₂S sensing†

Ho-Nam Mak,

^a Xuanyi Lu,^b Siyu Pan,^b Yanjuan Gu,

^a Lijun Jiang

*^ab and Wing-Tak Wong*^a

Author affiliations

* Corresponding authors

^a Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong SAR, China
E-mail: w.t.wong@polyu.edu.hk

^b Hubei Key Laboratory of Genetic Regulation & Integrative Biology, Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, School of Life Sciences, Central China Normal University, Wuhan 430079, China
E-mail: lijunjiang@ccnu.edu.cn

Abstract

We present a water-soluble fluorescence/MR dual-modality probe NBD[Gd] for H₂S detection. It showed 88.4% of fluorescence quenching and a 36% reduction in r₁ upon exposure to H₂S. It is readily uptaken by cells to sense the endogenous H₂S. Besides providing a bimodal H₂S imaging probe, our study also confirms the high H₂S level in CT26 cells and its functional consequence in promoting cell growth.

This article is part of the themed collection: 2024 Emerging Investigators

Download options Please wait...

Supplementary files

Supplementary information PDF (1098K)

Article information

DOI: https://doi.org/10.1039/D4CC05042H
Article type: Communication
Submitted: 27 Sep 2024
Accepted: 04 Nov 2024
First published: 06 Nov 2024

Download Citation

Chem. Commun., 2024, Advance Article

Permissions

Request permissions

A water-soluble Gd(III)-based fluorescence/T₁-MR dual-modality probe for H₂S sensing

H. Mak, X. Lu, S. Pan, Y. Gu, L. Jiang and W. Wong, Chem. Commun., 2024, Advance Article , DOI: 10.1039/D4CC05042H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Chemical Communications