A red turn-on fluorescent probe reveals elevated H2O2 in cell anesthesia

Longjie Du; Yu Ning; Wentao Li; Jianfei Kan; Jianchun Li; Jinhong Wang; Min Wang; Yanxiang Li; Jin Zhou

doi:10.1039/D4CC05267F

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A red turn-on fluorescent probe reveals elevated H₂O₂ in cell anesthesia†

Longjie Du,‡^a Yu Ning,‡^a Wentao Li,‡^a Jianfei Kan,^ac Jianchun Li,^a Jinhong Wang,*^a Min Wang,*^b Yanxiang Li^a and Jin Zhou

*^a

Author affiliations

* Corresponding authors

^a School of Pharmacy, School of Basic Medical Sciences, Shandong Second Medical University, Weifang 261053, China
E-mail: wfmcwjh@sdsmu.edu.cn, zhoujin@sdsmu.edu.cn

^b Shandong Sunshine Union Hospital Limited Liability Company, Weifang 261031, China
E-mail: wangmin6662024@163.com

^c Shandong Daizhuang Hospital, Jining 272000, China

Abstract

Cognitive dysfunction has become an important central nervous system (CNS)-related adverse reaction of intravenous anesthetics. Therefore, to further understand the role of H₂O₂, a potential marker of cognitive dysfunction, we constructed a fluorescent probe (LJ-1), which could specifically enable real-time detection of H₂O₂ in cells during anesthesia.

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Article information

DOI: https://doi.org/10.1039/D4CC05267F
Article type: Communication
Submitted: 08 Oct 2024
Accepted: 05 Nov 2024
First published: 05 Nov 2024

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Chem. Commun., 2024,60, 14443-14446

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A red turn-on fluorescent probe reveals elevated H₂O₂ in cell anesthesia

L. Du, Y. Ning, W. Li, J. Kan, J. Li, J. Wang, M. Wang, Y. Li and J. Zhou, Chem. Commun., 2024, 60, 14443 DOI: 10.1039/D4CC05267F

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Chemical Communications