Palladium-catalyzed directed site-selective C(sp3)–H alkylation of 8-methylquinolines has been accomplished using aziridine as the alkylating source via a sequential C–H and C–N bond activation process. The site selectivity, functional group tolerance and possible late-stage modifications are important practical features of this reaction.
A. Sahoo, T. Paul, S. Basak and T. Punniyamurthy, Chem. Commun., 2024, 60, 14818 DOI: 10.1039/D4CC05275G
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