Alder–ene reactions of arynes to form medium-sized and macrocyclic frameworks of sizes up to a 46-membered ring

Abstract

Macrocyclization via the intramolecular Alder–ene reaction of arynes to construct carbo- and hetero-macrocycles fused with an indoline or isoindoline moiety is described. By installing ether, ester, alkene, and cyclic tethers at an appropriate location between the aryne and the ene donor, macrocycles up to a 46-membered ring could be constructed.