From the journal:

Molecular Systems Design & Engineering

Dual-labelled polymeric micelles for singlet oxygen reporting in biological systems†

Yasuhiro Nakagawa, ORCID logo ‡abc   Hayato Laurence Mizuno,bc   Yuta Ushimaru,a   Jumpei Norimatsu,a   Kazunori Igarashi,ab   Keita Masuda,a   Madoka Takai, ORCID logo a   Yasutaka Anraku ORCID logo bc  and  Horacio Cabral ORCID logo *ab  

* Corresponding authors

a Department of Bioengineering, Graduated School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan
E-mail: horacio@bmw.t.u-tokyo.ac.jp

b Innovation Center of NanoMedicine, Kawasaki Institute of Industrial Promotion, 3-25-14 Tonomachi, Kawasaki-ku, Kawasaki, Japan

c Department of Materials Science and Engineering, Graduated School of Materials and Chemical Technology, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro-ku, Tokyo, Japan

Abstract

Visualizing singlet oxygen (1O2) in biological systems could greatly enhance our understanding of its biological roles and offer new diagnostics and therapeutics. However, 1O2 is unstable and highly reactive, making its detection in living systems a significant challenge. To address this, we have developed dually-labelled polymeric micelles designed to trace both the location and levels of 1O2.

Graphical abstract: Dual-labelled polymeric micelles for singlet oxygen reporting in biological systems

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Article information

DOI
https://doi.org/10.1039/D4ME00105B
Article type
Communication
Submitted
30 Jun 2024
Accepted
11 Nov 2024
First published
13 Nov 2024
This article is Open Access
Creative Commons BY license

Mol. Syst. Des. Eng., 2024, Advance Article

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Dual-labelled polymeric micelles for singlet oxygen reporting in biological systems

Y. Nakagawa, H. L. Mizuno, Y. Ushimaru, J. Norimatsu, K. Igarashi, K. Masuda, M. Takai, Y. Anraku and H. Cabral, Mol. Syst. Des. Eng., 2024, Advance Article , DOI: 10.1039/D4ME00105B

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