Synthesis of 3,3-disubstituted oxindoles from N-arylacrylamides and unactivated alkyl bromides via nickel-catalyzed cascade cyclization and their inhibitory effect on NO release

Abstract

A Ni-catalyzed cascade cyclization of N-acrylamides and unactivated alkyl bromides to synthesize 3,3-disubstituted oxindoles was reported. Up to 22 different oxindole derivatives were synthesized by this method and all the synthesized molecules were tested for inhibitory activity of nitric oxide release. The results show that 3,3-disubstituted oxindole is a potential scaffold to design new nitric oxide release inhibition drugs.