Dual-mode detection for the total antioxidant capability of skincare products based on porous CuS@CdS@Au nanoshells

Abstract

The antioxidants in skincare products play a crucial role in delaying the aging process of the skin. With the growing variety of cosmetic products, it is essential to develop effective methods for measuring their total antioxidant capability (TAC). This study introduces a novel nanoenyzme, CuS@CdS@Au nanoshells (NSs), characterized by porous morphologies and composite materials, which demonstrate remarkable localized surface plasmon resonance (LSPR) effects, thereby enhancing their photocatalytic and photothermal properties. Under 808 nm laser irradiation, these nano-enzymes exhibited superior catalytic ability for TMB oxidation and temperature increases compared to CuS or CuS @Au NSs. The TMB absorption response and temperature increase showed high sensitivity to antioxidants such as ascorbic acid, glutathione, and ferulic acid, enabling the development of a dual-mode detection strategy for quantifying the TAC in skincare products without the need for complex pretreatments. Furthermore, the temperature response-based detection results proved to be more accurate than those derived from absorption response in recovery experiments. This research not only improves the reliability of antioxidant assessments but also provides a valuable tool for quality control in the skincare industry.