Issue 10, 2024

A TEMPO promoted tandem reaction of 2-aminobenzophenones and benzylamines under electrochemical conditions

Abstract

This study describes the efficient synthesis of quinazolines promoted by TEMPO via electro-catalysis with 2-aminobenzophenones and benzylamines. The method exhibited remarkable chemoselectivity under mild reaction conditions. A series of quinazolines could be obtained in moderate to good yields. In addition, control experiments were carried out to verify the reaction mechanism. Furthermore, the synthesis on the gram scale was conducted successfully to give the target product.

Graphical abstract: A TEMPO promoted tandem reaction of 2-aminobenzophenones and benzylamines under electrochemical conditions

Supplementary files

Article information

Article type
Communication
Submitted
09 Jan 2024
Accepted
08 Feb 2024
First published
10 Feb 2024

Org. Biomol. Chem., 2024,22, 1983-1987

A TEMPO promoted tandem reaction of 2-aminobenzophenones and benzylamines under electrochemical conditions

Y. Wang, Y. Huang, Y. Li, K. Li and Z. Luo, Org. Biomol. Chem., 2024, 22, 1983 DOI: 10.1039/D4OB00037D

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