Issue 19, 2024

Visible light-driven photocatalytic sulfonative oxidation of benzyl secondary amines

Abstract

A method for the α-oxidation and sulfonation of benzyl secondary amines was developed utilizing Ir(III) or Eosin Y as the photocatalyst in the presence of O2 as a green oxidant. Using commercial substrates, 37 products from cyclic and acyclic benzylamines were achieved with good functional group compatibility in 48–87% yields. Furthermore, tetrahydroisoquinoline protected by an Ac or a Boc group was oxidized under standard conditions.

Graphical abstract: Visible light-driven photocatalytic sulfonative oxidation of benzyl secondary amines

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Article information

Article type
Paper
Submitted
03 Mar 2024
Accepted
18 Apr 2024
First published
23 Apr 2024

Org. Biomol. Chem., 2024,22, 3904-3909

Visible light-driven photocatalytic sulfonative oxidation of benzyl secondary amines

Y. Lü, X. Wang, Y. Pan and K. Ablajan, Org. Biomol. Chem., 2024, 22, 3904 DOI: 10.1039/D4OB00348A

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