Issue 18, 2024

Electrochemical nickel-catalyzed cross-coupling of glycosyl thiols with preactivated phenols and ketones

Abstract

An efficient electrochemical nickel-catalyzed cross-coupling reaction has been reported here for the synthesis of S-glycosides from preactivated phenols and ketones under mild conditions. Various glycosyl thiols, including unprotected sugar, and a diverse range of aryl/alkenyl triflates, including some complex biorelevant phenols and ketones, were well tolerated in this method.

Graphical abstract: Electrochemical nickel-catalyzed cross-coupling of glycosyl thiols with preactivated phenols and ketones

Supplementary files

Article information

Article type
Communication
Submitted
19 Mar 2024
Accepted
05 Apr 2024
First published
10 Apr 2024

Org. Biomol. Chem., 2024,22, 3597-3601

Electrochemical nickel-catalyzed cross-coupling of glycosyl thiols with preactivated phenols and ketones

F. Li, H. Liu, W. Xing, Q. Zhang and L. Wang, Org. Biomol. Chem., 2024, 22, 3597 DOI: 10.1039/D4OB00442F

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