Issue 35, 2024
From the journal:

Organic & Biomolecular Chemistry

A portal to highly valuable indole-functionalized vinyl sulfonyl fluorides and allylic sulfonyl fluorides†

Wenzhuo Huang,a   Eman Fayad,b   Ola A. Abu Alic  and  Hua-Li Qin ORCID logo *a  

* Corresponding authors

a State Key Laboratory of Silicate Materials for Architectures; and School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan 430070, China
E-mail: qinhuali@whut.edu.cn

b Department of Biotechnology, College of Sciences, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia
E-mail: e.esmail@tu.edu.sa

c Department of Chemistry, College of Science, Taif University, Taif 21944, Saudi Arabia
E-mail: o.abuali@tu.edu.sa

Abstract

A practical and efficient method for the C-3 site selective alkenylation of indoles was developed for constructing novel indole-functionalized vinyl sulfonyl fluorides and indolyl allylic sulfonyl fluorides. The reaction is accomplished with exclusive regio- and stereoselectivity without using transition metal catalysts, providing novel products of great potential value in medicinal chemistry, chemical biology, and drug discovery.

Graphical abstract: A portal to highly valuable indole-functionalized vinyl sulfonyl fluorides and allylic sulfonyl fluorides

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Article information

DOI
https://doi.org/10.1039/D4OB01213E
Article type
Communication
Submitted
23 Jul 2024
Accepted
12 Aug 2024
First published
16 Aug 2024

Org. Biomol. Chem., 2024,22, 7117-7120

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A portal to highly valuable indole-functionalized vinyl sulfonyl fluorides and allylic sulfonyl fluorides

W. Huang, E. Fayad, O. A. Abu Ali and H. Qin, Org. Biomol. Chem., 2024, 22, 7117 DOI: 10.1039/D4OB01213E

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