Pd-catalyzed vinyl C–H amination with diaziridinone

Abstract

This work describes a Pd-catalyzed vinyl C–H amination of N-(quinolin-8-yl)acrylamides with di-t-butyldiaziridinone, providing ready access to a variety of 3-amino-N-(quinolin-8-yl)acrylamides. The reaction likely proceeds via vinyl C–H activation to form a pallada(II)cycle and subsequent amination with di-t-butyldiaziridinone.