Issue 8, 2024

Advancement in the C–H bond alkylation of (hetero)arenes catalyzed by the most abundant transition metal–iron

Abstract

Alkylation reaction stands as a crucial organic transformation, fostering privileged alkylated arenes and heteroarenes in molecular science. Over the past decade, the utilization of the most abundant transition metal iron for regioselective C–H bond alkylation has gained substantial prominence, offering a straightforward and sustainable approach. Noteworthy progress has been achieved in the alkylation of diverse arenes and heteroarenes involving primary, secondary, and tertiary alkyl (pseudo)halide, alkene, and alcohol coupling partners via both the mono- and bidentate-chelate strategies. This concise and focused review provides an overview of the advancement in the iron-catalyzed alkylation of arenes and heteroarenes through step-economical C–H functionalization, their novel features, proposed mechanisms, and future research directions. The review is categorized into two major sections: (i) alkylation of arenes and (ii) alkylation of heteroarenes. Each section is discussed based on the class of arenes and heteroarenes used.

Graphical abstract: Advancement in the C–H bond alkylation of (hetero)arenes catalyzed by the most abundant transition metal–iron

Article information

Article type
Review Article
Submitted
10 Jan 2024
Accepted
06 Mar 2024
First published
07 Mar 2024

Org. Chem. Front., 2024,11, 2397-2417

Advancement in the C–H bond alkylation of (hetero)arenes catalyzed by the most abundant transition metal–iron

C. Pradhan and B. Punji, Org. Chem. Front., 2024, 11, 2397 DOI: 10.1039/D4QO00063C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements