Issue 14, 2024

Strategic convergent synthesis en route to Veratrum steroidal alkaloids

Abstract

Veratrum steroidal alkaloids are highly intricate alkaloids with a C-nor-D-homo steroid skeleton linked to a piperidine ring. These alkaloids have fascinated researchers due to their structural complexity and biological properties. The first synthesis of cyclopamine was accomplished in 2009 via a semi-synthetic approach. More recently, the synthesis of Veratrum steroidal alkaloids has made significant progress, employing a convergent approach. In this Highlight, we discuss the synthetic strategy that yields the highly functionalized, complex molecular architecture of Veratrum steroidal alkaloids, emphasizing key reactions involved. We also explore the current state of the synthesis of Veratrum steroidal alkaloids and discuss future directions and opportunities for the convergent synthetic approach in complex natural product synthesis.

Graphical abstract: Strategic convergent synthesis en route to Veratrum steroidal alkaloids

Article information

Article type
Highlight
Submitted
20 Apr 2024
Accepted
05 Jun 2024
First published
10 Jun 2024

Org. Chem. Front., 2024,11, 4014-4023

Strategic convergent synthesis en route to Veratrum steroidal alkaloids

Z. Wang, Org. Chem. Front., 2024, 11, 4014 DOI: 10.1039/D4QO00717D

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