Issue 17, 2024

Recent advances in post Ugi-4CR dearomatizations for constructing spiro heterocycles

Abstract

The Ugi reaction has obtained broad interest due to mild reaction conditions and high variability. The Ugi adducts provide myriad opportunities for post-transformations, leading to heterocycles, bioactive molecules, macrocycles, polymers, natural products and drugs. Recently, dearomatization strategies have been employed in post-Ugi transformations. Through transition metal catalysis and metal-free methods, different kinds of three dimensional complex molecules are formed in an atom- and step-economic manner. This review summarizes recent advances in the combination of the Ugi-4CR and dearomatization strategies for the synthesis of spirocycles.

Graphical abstract: Recent advances in post Ugi-4CR dearomatizations for constructing spiro heterocycles

Article information

Article type
Review Article
Submitted
10 Jun 2024
Accepted
12 Jul 2024
First published
12 Jul 2024

Org. Chem. Front., 2024,11, 4895-4912

Recent advances in post Ugi-4CR dearomatizations for constructing spiro heterocycles

X. Tang, Q. Tao, L. Song and E. V. Van der Eycken, Org. Chem. Front., 2024, 11, 4895 DOI: 10.1039/D4QO01060D

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