Photoelectrochemical synthesis of 4-halomethyl benzoxazines with a halogen anion source

Abstract

Benzoxazine is an important motif in various pharmaceuticals and functional molecules. We herein described a visible-light induced photoelectrochemical strategy for the synthesis of 4-halomethyl benzoxazines with an organo-photocatalyst. In the present protocol, a series of olefinic amides can be transformed into 4-halomethyl benzoxazines via oxyhalogenation with nBu₄NX as the halogenating reagent, showing good functional group tolerance.