Asymmetric synthesis of (aza)flavanones by the evolution of CarOx ligands

Abstract

Amino-pyridine-oxazoline (NHPyOx) is conceived as an unprecedented model via the core-emulating optimization of CarOx ligands. The facile and programmable modifiability led to a new ligand repertoire for the Pd-catalyzed Hayashi–Miyaura coupling of arylboronic acids with 4-quinolones or electron-deficient chromones (>35 examples, up to 97% yield, 97% ee).