Enantioselective construction of planar, axially and central chiral ferrocenyl phosphines via a Pd-catalyzed domino reaction and diastereoselective phosphination

Abstract

A family of both axially and planar chiral ferrocene systems was synthesized through a Pd-catalyzed domino reaction, affording remarkable results (up to 76% yield) with excellent enantioselectivities (up to 99% ee) and diastereoselectivities (up to >20 : 1 dr). The products were thereafter transformed into ferrocenyl phosphines, featuring all central, planar and axial chiralities, exhibiting excellent diastereoselectivities. The Pd-catalyzed enantioselective allylic alkylation reaction demonstrated the potential application of the novel developed ligand, which showcased remarkable enantioselectivity (99% ee).