Issue 19, 2024, Issue in Progress

Development of an imidazole-based N,N-bidentate ligand for the manganese catalyzed direct coupling of nitriles with alcohols

Abstract

3d-Metal catalyzed borrowing hydrogen (BH) reactions represent powerful and environmentally friendly approaches for the direct coupling of alcohols with nitriles to assemble various important branched nitriles. The development of simple and efficient ligands is a crucial issue in this field. In this study, we designed a series of readily available N,N-bidentate ligands that demonstrated good efficiency in the Mn-catalyzed BH reaction of alcohols and nitrile derivatives, yielding the targeted nitriles in moderate to good yields. Remarkably, the mildness and practicality of this protocol were further demonstrated by the successful synthesis of anipamil via a two-cascade borrowing hydrogen procedure.

Graphical abstract: Development of an imidazole-based N,N-bidentate ligand for the manganese catalyzed direct coupling of nitriles with alcohols

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Article information

Article type
Paper
Submitted
01 Feb 2024
Accepted
15 Apr 2024
First published
22 Apr 2024
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2024,14, 12978-12982

Development of an imidazole-based N,N-bidentate ligand for the manganese catalyzed direct coupling of nitriles with alcohols

Q. Tang, D. Song, K. Zhang, W. Mao, X. Zhao, D. Du, F. Ling and W. Zhong, RSC Adv., 2024, 14, 12978 DOI: 10.1039/D4RA00817K

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