Issue 12, 2024, Issue in Progress
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RSC Advances

An antiviral oligomerized linear thiopeptide with a nitrile group from soil-derived Streptomyces sp. CPCC 203702†

Zhe Guo,‡a   Dewu Zhang, ORCID logo ‡*a   Yujia Wang,b   Jinglin Bai,ab   Jun Hu,a   Shan Cenb  and  Liyan Yu*ab  

* Corresponding authors

a China Pharmaceutical Culture Collection, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China
E-mail: zhangdewuever@163.com, yly@cpcc.ac.cn

b Division for Medicinal Microorganisms Related Strains, CAMS Collection Center of Pathogenic Microorganisms, Beijing 100050, People's Republic of China

Abstract

A new linear thiopeptide, bernitrilecin (1), was isolated from Streptomyces sp. CPCC 203702. Compound 1 is the first example of a nitrile-bearing thiopeptide. Its structure and absolute configuration were elucidated by extensive analysis of spectroscopic data and Marfey's method. The biosynthesis of the nitrile unit for 1 was proposed to be through oxidations, decarboxylation, and dehydration. Compound 1 exhibited significant anti-influenza A virus activity with the IC50 value of 16.7 μM.

Graphical abstract: An antiviral oligomerized linear thiopeptide with a nitrile group from soil-derived Streptomyces sp. CPCC 203702

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Article information

DOI
https://doi.org/10.1039/D4RA01496K
Article type
Paper
Submitted
27 Feb 2024
Accepted
05 Mar 2024
First published
11 Mar 2024
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2024,14, 8260-8263

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An antiviral oligomerized linear thiopeptide with a nitrile group from soil-derived Streptomyces sp. CPCC 203702

Z. Guo, D. Zhang, Y. Wang, J. Bai, J. Hu, S. Cen and L. Yu, RSC Adv., 2024, 14, 8260 DOI: 10.1039/D4RA01496K

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