KI mediated one-pot cascade reaction for synthesis of 1,3,4-selenadiazoles

Abstract

An efficient catalytic system consisting of KI and K₂S₂O₈ for a one-pot pseudo three-component cascade reaction in the preparation of a diverse array of 1,3,4-selenadiazole derivatives from easily accessible precursors aldehydes, hydrazine and elemental selenium is demonstrated in this paper. Here, KI is used as the surrogate of iodine and K₂S₂O₈ as the oxidant. The key advantages of this protocol include an easy reaction set up, operational simplicity, high functional group tolerance and utilisation of low toxicity chemicals. Further, a radical quenching reaction was also performed to confirm the mechanistic pathway.