Issue 43, 2024

Single-molecule detection of modified amino acid regulating transcriptional activity

Abstract

Acetylation of lysine, a component of histones, regulates transcriptional activity. Simple detection methods for acetyl lysine are essential for early diagnosis of diseases and understanding of the physiological effects. We have detected and recognized acetyl lysine at the single-molecule level by combining MCBJ measurement and machine learning.

Graphical abstract: Single-molecule detection of modified amino acid regulating transcriptional activity

Supplementary files

Article information

Article type
Paper
Submitted
29 Jul 2024
Accepted
20 Sep 2024
First published
07 Oct 2024
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2024,14, 31740-31744

Single-molecule detection of modified amino acid regulating transcriptional activity

Y. Komoto, T. Ohshiro, Y. Notsu and M. Taniguchi, RSC Adv., 2024, 14, 31740 DOI: 10.1039/D4RA05488A

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements