Issue 39, 2024

Facile construction of 2-pyrones under carbene catalysis

Abstract

2-Pyrones are valuable structural motifs in organic chemistry, found in numerous natural products and pharmaceuticals. The synthesis of these heterocycles has been significantly advanced by the application of N-Heterocyclic Carbene (NHC) catalysis. This review examines the recent advancements in NHC-catalyzed synthesis of 2-pyrones, highlighting key methodologies, mechanisms, and synthetic applications. NHC catalysis has revolutionized the synthesis of 2-pyrones, providing efficient, selective, and versatile methods for constructing these valuable heterocycles.

Graphical abstract: Facile construction of 2-pyrones under carbene catalysis

Article information

Article type
Review Article
Submitted
01 Aug 2024
Accepted
02 Sep 2024
First published
06 Sep 2024
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2024,14, 28585-28595

Facile construction of 2-pyrones under carbene catalysis

M. Yu, J. Huang, H. Zhu, D. Shi, W. Yang, Y. Liu, Y. Ji and Z. Fu, RSC Adv., 2024, 14, 28585 DOI: 10.1039/D4RA05596A

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