Total synthesis of bicyclomahanimbine by Cu(ii)-promoted photoredox process

Abstract

Since the isolation of carbazole alkaloids, the synthetic chemists have witnessed an upsurge in research of them due to their potential pharmacological properties. Our approach shows the total syntheses of five such biorelevant pyrano-[3,2a]-carbazole alkaloids, emphasizing biomimetic and innovative synthetic methodologies such as cascade reactions and strategic bond formations through sustainable electrochemical and photochemical conditions.