Issue 43, 2024

High-efficiency detection of primary amine-based chiral molecules by a facile aldimine condensation reaction

Abstract

Detection of chiral molecules in a high-efficiency way is very important to meet the demands for chiral analysis in drug testing, asymmetric synthesis, etc. Herein, we have developed a novel route to realize the rapid determination of concentration and configuration of primary amine-based chiral molecules. An aldehyde functionalized acid & base-sensitive fluorane dye (R–C) was used as the active agent to be reacted with the chiral molecules through an aldimine condensation reaction. After the mixing operation, concentration and configuration of the detected chiral molecule could be facilely read from the UV-vis absorption spectra and CD spectra, respectively.

Graphical abstract: High-efficiency detection of primary amine-based chiral molecules by a facile aldimine condensation reaction

Supplementary files

Article information

Article type
Paper
Submitted
31 Aug 2024
Accepted
04 Oct 2024
First published
08 Oct 2024
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2024,14, 31820-31824

High-efficiency detection of primary amine-based chiral molecules by a facile aldimine condensation reaction

Y. Yu, A. Shi, T. Wang, T. Wang and F. Xu, RSC Adv., 2024, 14, 31820 DOI: 10.1039/D4RA06291D

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements