Issue 43, 2024

Improving the sulfite-detection performance of a fluorescent probe via post-synthetic modification with a metal–organic framework

Abstract

In this work, a post-synthetic modification strategy was attempted to improve the performance of the probe for sulfite detection. The assembled platform UiO-66-NH-DQA, which was acquired by anchoring the sulfite-response fluorescent probe DQA onto the surface of UiO-66-NH2via amide covalent bonds, exhibited enhanced fluorescence intensity and practical intracellular imaging capability. In spite of the structural similarity, as verified by characterization tests, the conversion rate of post-synthetic modification was calculated as 35%, equaling an approximate assembly ratio of 1 : 2 between UiO-66-NH2 and DQA. Most significantly, conversion into UiO-66-NH-DQA led to a 5.6-fold enhancement in the reporting signal with a red shift of 20 nm. For sulfite detection, the linear range was 0–150 μM, with a limit of detection value of 0.025 μM. UiO-66-NH-DQA retained advantages including high stability (within pH 5.0–9.0), rapid response (within 15 min) and high selectivity. Based on low cytotoxicity and relatively rapid cellular uptake, UiO-66-NH-DQA achieved the imaging of both the exogenous and endogenous sulfite levels in living cells. In particular, its rapid cell-permeating capability was guaranteed during the modification. The post-synthetic modification strategy reported herein has potential for improving the practical properties of fluorescent monitoring materials.

Graphical abstract: Improving the sulfite-detection performance of a fluorescent probe via post-synthetic modification with a metal–organic framework

Supplementary files

Article information

Article type
Paper
Submitted
07 Aug 2024
Accepted
25 Sep 2024
First published
25 Sep 2024

J. Mater. Chem. B, 2024,12, 11251-11258

Improving the sulfite-detection performance of a fluorescent probe via post-synthetic modification with a metal–organic framework

J. Shi, B. Wang, X. Cui, X. Hu, H. Zhu and Y. Yang, J. Mater. Chem. B, 2024, 12, 11251 DOI: 10.1039/D4TB01754D

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