Reasonable construction of a bimetallic organic framework MIL-88B (Fe, Ni) nanoenzyme based on deep learning assisted doxycycline hydrochloride and methyloxytetracycline hydrochloride

Abstract

Developing a real-time and effective monitor of antibiotic residues in the environment is still a challenge. The bimetallic organic framework nanoenzyme MIL-88B (Fe, Ni) was simply synthesized using a solvothermal method. MIL-88B (Fe, Ni) with an excellent peroxidase activity could catalyze H₂O₂ to produce O₂˙⁻ and OH. FTIR and DFT results found that the introduction of Ni²⁺ to replace a portion of Fe³⁺ formed rich Fe₂NiO clusters, which could reduce the energy consumption of the reaction rate determining step. Based on its high peroxidase activity, a multifunctional colorimetric detection platform for DOX and MET was successfully constructed, with real-time and rapid detection capabilities. The linear ranges of MET and DOX were both 5–135 μM, with a minimum detection limit of 0.8524 μM and 1.0553 μM, respectively. Above all, this study has shown great potential in detecting antibiotic residues in environmental soil and water.