From the journal:

Analytical Methods

Rational construction of a simplified hemicyanine-based fluorescent probe CCX-1 with dual pH and viscosity response for lysosome-specific tumour imaging†

Qingxiu Chen,‡a   Shuanglong Li,‡a   Shun Li,a   Peipei Tong,a   Ruping Li,a   Jiaqiang Wu, ORCID logo *b   Chunli Xia*a  and  Daoyuan Chen ORCID logo *a  

* Corresponding authors

a School of Bioengineering, Zhuhai Campus of Zunyi Medical University, Zhuhai 519090, China
E-mail: chendaoyuan@zmuzh.edu.cn, xiachl@zmu.edu.cn

b School of Pharmacy and Food Engineering, Wuyi University, Jiangmen 529020, China
E-mail: wyuchemwjq@wyu.edu.cn

Abstract

A simplified D–π–A hemicyanine probe CCX-1 was rationally designed and synthesised via a one-step condensation reaction. CCX-1 exhibits dual-responsive fluorescence behavior towards pH and viscosity changes, along with specific lysosomal targeting capability. Notably, CCX-1 enables discrimination between tumor and normal cells, and tumor visualization in living mice, showing significant potential for precise cancer imaging and diagnosis.

Graphical abstract: Rational construction of a simplified hemicyanine-based fluorescent probe CCX-1 with dual pH and viscosity response for lysosome-specific tumour imaging

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Article information

DOI
https://doi.org/10.1039/D5AY00577A
Article type
Communication
Submitted
05 Apr 2025
Accepted
16 May 2025
First published
28 May 2025

Anal. Methods, 2025, Advance Article

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Rational construction of a simplified hemicyanine-based fluorescent probe CCX-1 with dual pH and viscosity response for lysosome-specific tumour imaging

Q. Chen, S. Li, S. Li, P. Tong, R. Li, J. Wu, C. Xia and D. Chen, Anal. Methods, 2025, Advance Article , DOI: 10.1039/D5AY00577A

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