Calibration free approaches for rapid polymorph discrimination via low frequency (THz) Raman spectroscopy

Magdalene W. S. Chong; Martin R. Ward; Catriona McFarlan; Andrew J. Parrott; Paul Dallin; John Andrews; Iain D. H. Oswald; Alison Nordon

doi:10.1039/D4CC05591H

Calibration free approaches for rapid polymorph discrimination via low frequency (THz) Raman spectroscopy†

Magdalene W. S. Chong,

*^ab Martin R. Ward,

^ac Catriona McFarlan,

^b Andrew J. Parrott,

^b Paul Dallin,^d John Andrews,^d Iain D. H. Oswald

^c and Alison Nordon

*^ab

Author affiliations

* Corresponding authors

^a EPSRC Future Continuous Manufacturing and Advanced Crystallisation Research Hub, University of Strathclyde, 99 George Street, Glasgow, UK
E-mail: magdalene.chong@strath.ac.uk, alison.nordon@strath.ac.uk

^b WestCHEM, Department of Pure and Applied Chemistry, Centre for Process Analytics and Control Technology (CPACT), University of Strathclyde, 295 Cathedral Street, Glasgow, UK

^c Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow, UK

^d Clairet Scientific, 17/18 Scirocco Close, Moulton Park Industrial Estate, Northampton, UK

Abstract

Application of multivariate curve resolution to non-invasive Raman spectra has been investigated for rapid on-line analysis of crystallisation processes and high-throughput screening. Exploring quantification of mefenamic acid solid forms (form I, form II, and dimethylformamide solvate) from the Raman spectra indicated excellent agreement with off-line X-ray analysis.

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Article information

DOI: https://doi.org/10.1039/D4CC05591H
Article type: Communication
Submitted: 20 Oct 2024
Accepted: 06 Dec 2024
First published: 06 Dec 2024
This article is Open Access

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Chem. Commun., 2025,61, 925-928

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Calibration free approaches for rapid polymorph discrimination via low frequency (THz) Raman spectroscopy

M. W. S. Chong, M. R. Ward, C. McFarlan, A. J. Parrott, P. Dallin, J. Andrews, I. D. H. Oswald and A. Nordon, Chem. Commun., 2025, 61, 925 DOI: 10.1039/D4CC05591H

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Chemical Communications

Calibration free approaches for rapid polymorph discrimination via low frequency (THz) Raman spectroscopy†

Abstract

Supplementary files

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Calibration free approaches for rapid polymorph discrimination via low frequency (THz) Raman spectroscopy

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