A ratiometric two-photon fluorescent probe for the quantification of nitroreductase in hypoxic neurons

Zhiquan Tang; Hong Huang; Yuanyuan Yao; Shumei Gao; Bingyong Lin; Qianshou Zong; Wanpeng Hu; Jianguo Xu; Yangang Wang; Longhua Guo

doi:10.1039/D4CC06218C

A ratiometric two-photon fluorescent probe for the quantification of nitroreductase in hypoxic neurons†

Zhiquan Tang,^a Hong Huang,

*^a Yuanyuan Yao,

^a Shumei Gao,^a Bingyong Lin,^a Qianshou Zong,^a Wanpeng Hu,*^a Jianguo Xu,

^a Yangang Wang^a and Longhua Guo

*^a

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* Corresponding authors

^a College of Biological, Chemical Science and Engineering, Jiaxing University, Jiaxing 314001, China
E-mail: huangho17@zjxu.edu.cn, huangho17@163.com, hu688@zjxu.edu.cn, guolh@zjxu.edu.cn

Abstract

We developed a novel ratiometric two-photon fluorescent probe for the selective and precise detection of nitroreductase (NTR) in neurons. Using this probe, we found that hypoxic stimulation could up-regulate endogenous NTR levels.

Chemical Communications

A ratiometric two-photon fluorescent probe for the quantification of nitroreductase in hypoxic neurons†

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A ratiometric two-photon fluorescent probe for the quantification of nitroreductase in hypoxic neurons

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