Construction of a hydrogen-bonded organic framework-based therapeutic platform by one-pot method

Yan Wang; Jiarui Qiao; Wenjing Wei; Meng Liu; Xianhao Wei; Luwen Zhang; Junhe Ou; Tingyan Jiang; Maolin Pang

doi:10.1039/D4CC06409G

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Construction of a hydrogen-bonded organic framework-based therapeutic platform by one-pot method†

Yan Wang,^a Jiarui Qiao,^a Wenjing Wei,^a Meng Liu,^a Xianhao Wei,^a Luwen Zhang,^a Junhe Ou,^a Tingyan Jiang^a and Maolin Pang

*^a

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* Corresponding authors

^a School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541001, P. R. China
E-mail: mlpang@gxnu.edu.cn

Abstract

The anticancer drug camptothecin (CPT) was successfully in situ loaded into a hydrogen-bonded organic framework (HOF) by one-pot method with a high loading efficiency of 42 wt%. The resultant HOF based therapeutic platform could suppress the tumor growth effectively.

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Article information

DOI: https://doi.org/10.1039/D4CC06409G
Article type: Communication
Submitted: 04 Dec 2024
Accepted: 28 Jan 2025
First published: 30 Jan 2025

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Chem. Commun., 2025,61, 3560-3563

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Construction of a hydrogen-bonded organic framework-based therapeutic platform by one-pot method

Y. Wang, J. Qiao, W. Wei, M. Liu, X. Wei, L. Zhang, J. Ou, T. Jiang and M. Pang, Chem. Commun., 2025, 61, 3560 DOI: 10.1039/D4CC06409G

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Chemical Communications

Construction of a hydrogen-bonded organic framework-based therapeutic platform by one-pot method†

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Construction of a hydrogen-bonded organic framework-based therapeutic platform by one-pot method

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