Near-infrared 10B-BODIPY for precise guidance of tracer imaging and treatment in boron neutron capture therapy

Wenyong Huang; Yong Pan; Tianyuan Zhong; Shasha He; Yanxin Qi; Yubin Huang

doi:10.1039/D5CC01671A

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Near-infrared ¹⁰B-BODIPY for precise guidance of tracer imaging and treatment in boron neutron capture therapy†

Wenyong Huang,^a Yong Pan,^a Tianyuan Zhong,^a Shasha He,

*^b Yanxin Qi*^a and Yubin Huang

*^a

Author affiliations

* Corresponding authors

^a Faculty of Chemistry, Northeast Normal University, Changchun 130024, P. R. China

^b State Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province (IKKEM), Xiamen University, Xiamen 361005, China

Abstract

A new near-infrared fluorescence probe (PBA-BDP) was developed by coupling boron-10 (¹⁰B) to a phenylboronic acid (PBA)-functionalized BODIPY dye. This multifunctional probe not only delivers ¹⁰B for boron neutron capture therapy (BNCT) but also enhances tumor-specific targeting and provides dynamic insight into boron distribution during treatment.

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Article information

DOI: https://doi.org/10.1039/D5CC01671A
Article type: Communication
Submitted: 25 Mar 2025
Accepted: 13 May 2025
First published: 13 May 2025

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Chem. Commun., 2025, Advance Article

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Near-infrared ¹⁰B-BODIPY for precise guidance of tracer imaging and treatment in boron neutron capture therapy

W. Huang, Y. Pan, T. Zhong, S. He, Y. Qi and Y. Huang, Chem. Commun., 2025, Advance Article , DOI: 10.1039/D5CC01671A

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