Cu(I)/Pd(0) Cooperative Catalysis Enabled Regioselective C(sp2)-Carboboration of 1,3-Diynes

Abstract

We present a regioselective C(sp²)-carboboration of 1,3-diynes using CuI/Pd0 cooperative catalysis, enabling access to a diverse range of conjugated aryl-substituted boryl enynes. Furthermore, sequential proto-/ carbo-/di-boration strategies afforded highly conjugated multi-boron-substituted dienes. Cross-coupling of the boron end groups facilitated the modular synthesis of highly conjugated enynes and dienes with intriguing properties.