Direct Measurement of SARS-CoV-2 Spike RBD Binding to Integrin αvβ6 by Single-Molecule Force Spectroscopy

Abstract

Single-molecule force spectroscopy reveals strong, cation-dependent binding between SARS-CoV-2 RBD and integrin αvβ6, with rupture forces exceeding ACE2, supporting integrin αvβ6 as an alternative receptor.

Article information

Article type
Communication
Submitted
29 May 2025
Accepted
29 Jul 2025
First published
29 Jul 2025

Chem. Commun., 2025, Accepted Manuscript

Direct Measurement of SARS-CoV-2 Spike RBD Binding to Integrin αvβ6 by Single-Molecule Force Spectroscopy

T. Feng, F. Tian, J. Li, X. Dong, B. Tong and P. Zheng, Chem. Commun., 2025, Accepted Manuscript , DOI: 10.1039/D5CC03034J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements