Three-Component Reaction of Isocyanates and 3-Aminoacrylates: Selective Synthesis of N-2-Aryl-1,2,3-Triazoles and Hydrazones

Abstract

This study presents a novel three-component reaction of nitrogen sources, 3-aminoacrylates and isocyanates, enabling the condition-controlled selective synthesis of N-2-aryl 1,2,3-triazoles and polyfunctionalized hydrazones. In this transformation, (NH4)2Ce(NO3)6 and TBN, in combination with isocyanates, serve as nitrogen sources, replacing conventional hydrazine or diazo reagents. This process involves the construction of two N-N bonds, demonstrating broad substrate compatibility and excellent functional group tolerance.