Doxorubicin carrier based on an HCOF platform for potent cancer therapy

Abstract

Doxorubicin is widely used in cancer treatment, and an effective drug carrier is usually needed to overcome its serious side effects. In this study, a highly monodisperse hollow covalent organic framework (HCOF) was prepared using a two-step method, and then was loaded with DOX with a high loading efficiency of 41.2 wt%. In vivo studies demonstrated excellent antitumor efficacy.