Dietary strategies for appetite regulation: satiety and obesity management

Abstract

Increased prevalence of diseases associated with obesity has driven research into appetite suppression to reduce high-calorie intake. Dietary modulation of appetite is recognized as one of the most significant and effective ways to reduce the risk of obesity-related diseases. This review evaluates the roles of dietary nutrients and their metabolites in satiety and proposes dietary strategies for appetite regulation. Brain circuits of hunger, hormones and organs that directly control the appetite, and the role of gut microbiota in indirect appetite modulation are discussed in detail. We explored the impact of dietary nutrients and their metabolites on appetite, based on the basic mechanics of hunger. Additionally, based on the impact of different dietary factors on satiety, we outlined three strategies for appetite regulation: systems for controlled nutrient delivery to decelerate digestion, alteration of dietary physicochemical characteristics, and establishment of dietary rhythms. This review presents a theoretical framework for examining the influence of dietary nutrition on appetite regulation.