Photoinduced carbonylative multicomponent reaction of anilines and arylaldehydes

Abstract

While the carbonyl alkylation amination of alkyl aldehydes has been established as a powerful strategy for accessing tertiary amines, analogous transformations involving aryl aldehydes remain underexplored. Herein, we introduce a photoinduced carbonylative amination strategy with arylaldehydes, enabling the efficient synthesis of valuable α-aminoketones. This transformation features a four-component reaction wherein carbon monoxide acts as a carbonyl source and aniline serves as the amine moiety. The method proceeds under mild, photoinduced conditions and provides a streamlined, atom-economical approach to structurally diverse α-aminoketones through a one-pot one-step protocol.