Synthetic Molecular Communication Through Microfluidic Oscillating Droplets for Intrabody Physiological Data Transmission

Abstract

We explore the capabilities of a microfluidic-based Synthetic Molecular Communication (SMC) sys-tem for the transmission of physiological data within the human body. The system employs oscillating water droplets to transmit information via pressure variations. Simulations and experiments validate the feasibility of this approach for binary communications. A case study focused on monitoring gas-troesophageal reflux disease (GERD) has been considered. A prototype platform successfully trans-mitted both raw esophageal pH synthetic values and severity classifications (acid reflux, etc.) using oscillating droplets. This demonstrates the potential of SMC for real-time physiological monitoring, paving the way for improved disease diagnosis and personalized treatment in medicine. Although miniaturization is needed for in-vivo use, this research lays a strong foundation for developing micro-fluidic SMC devices for medical diagnostics and physiological monitoring

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Article information

Article type
Paper
Submitted
09 Nov 2024
Accepted
14 Feb 2025
First published
25 Feb 2025
This article is Open Access
Creative Commons BY-NC license

Lab Chip, 2025, Accepted Manuscript

Synthetic Molecular Communication Through Microfluidic Oscillating Droplets for Intrabody Physiological Data Transmission

F. Pappalardo, C. Panarello, S. Quattropani, L. Galluccio, A. Licciardello, R. Ruffino, G. Li Destri, A. Lombardo, G. Morabito and N. Tuccitto, Lab Chip, 2025, Accepted Manuscript , DOI: 10.1039/D4LC00944D

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