Furanone-based Comonomer Used to Manufacture Antibacterial Bone Cement with Simultaneously Enhanced Mechanical Strength and Antibacterial Activity

Abstract

A furanone-based methacrylate carbamate comonomer has been reported, which we named FUMA. With this comonomer in hand, a new type of FUMA bone cement was manufactured. Surprisingly, the mechanical strength of the FUMA cement increased with the monomer content, meeting the ISO 5833 requirements. Further studies showed that, the antibacterial activity of the FUMA cement increased with higher monomer content, and the 25% FUMA cement exhibited 97.57 ± 2.27% antibacterial activity against Staphylococcus aureus and 43 ± 4.82% against methicillin-resistant Staphylococcus aureus (MRSA). This cement demonstrated no hemolytic activity or acute toxicity. These findings provide new potential approaches for the prevention of periprosthetic joint infections (PJIs).