An AlFe2O4@SiO2–SO3H innovative nanocatalyst: a sustainable approach for the A3 coupling reaction in a DES for 2-thioarylbenzoazoles

Abstract

The A3 coupling reaction, which facilitates the synthesis of 2-thioarylbenzoazoles, represents a significant transformation in organic chemistry with implications in drug discovery and materials science. In this study, we introduce a novel nanocatalyst, AlFe2O4@SiO2–SO3H, designed to enhance the efficiency and sustainability of this reaction. The catalyst is synthesized by functionalizing aluminum ferrite (AlFe2O4) with chlorosulfonic acid (Cl–SO3H), promoting its role as an effective acid catalyst. Utilizing deep eutectic solvents (DESs) as a green reaction medium further contributes to the sustainability of the process by providing a biodegradable and non-toxic environment. Optimization studies were conducted to determine the optimal reaction conditions, including catalyst loading, temperature, and solvent composition. Characterization of the nanocatalyst was performed using techniques such as X-ray diffraction (XRD), scanning electron microscopy (SEM), and Fourier-transform infrared spectroscopy (FTIR) to confirm successful synthesis and functionalization. The AlFe2O4@SiO2–SO3H nanocatalyst exhibited excellent catalytic activity, resulting in high yields of 2-thioarylbenzoazoles under mild conditions while allowing for easy recovery and reuse without significant loss of activity. This work demonstrates the potential of AlFe2O4@SiO2–SO3H as a sustainable catalytic system for A3 coupling reactions, contributing to the development of environmentally friendly methodologies in organic synthesis.

Graphical abstract: An AlFe2O4@SiO2–SO3H innovative nanocatalyst: a sustainable approach for the A3 coupling reaction in a DES for 2-thioarylbenzoazoles

Supplementary files

Article information

Article type
Paper
Submitted
15 Mar 2025
Accepted
02 May 2025
First published
08 May 2025
This article is Open Access
Creative Commons BY license

Nanoscale Adv., 2025, Advance Article

An AlFe2O4@SiO2–SO3H innovative nanocatalyst: a sustainable approach for the A3 coupling reaction in a DES for 2-thioarylbenzoazoles

A. Sajjadi, S. V. Mayani, S. Ballal, S. Al-Hasnaawei, A. Singh, K. Chennakesavulu and K. K. Joshi, Nanoscale Adv., 2025, Advance Article , DOI: 10.1039/D5NA00247H

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements