Issue 7, 2025
From the journal:

New Journal of Chemistry

Metal-coordination-driven self-assembly of DNA nanohybrids for robust intracellular anti-tuberculosis therapy†

Kaidi Zhang,‡ab   Hong Sun,‡b   Xingchen Gao,b   Tong Liang,b   Xiaoyi Gao,b   Houhui Song,*a   Chiyu Guan,*a   Zhaogang Sun ORCID logo *b  and  Jingfang Zhang ORCID logo *b  

* Corresponding authors

a Key Laboratory of Applied Biotechnology on Animal Science & Veterinary Medicine of Zhejiang Province, Zhejiang Engineering Research Center for Veterinary Diagnostics & Advanced Technology, Zhejiang International Science and Technology Cooperation Base for Veterinary Medicine and Health Management, Belt and Road International Joint Laboratory for One Health and Food Safety, China-Australia Joint Laboratory for Animal Health Big Data Analytics, College of Veterinary Medicine of Zhejiang A&F University, 666 Wusu Street, Lin’an District, Hangzhou, Zhejiang Province, China
E-mail: songhh@zafu.edu.cn, 20190046@zafu.edu.cn

b Translational Medicine Center, Beijing Chest Hospital, Capital Medical University/Beijing Key Laboratory in Drug Resistant Tuberculosis Research, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, China
E-mail: zhangjingfang@bjxkyy.cn, sunzhaogang@bjxkyy.cn

Abstract

Due to traditional antibiotics’ limitations in treating tuberculosis (TB), this study presents a DNA-based nanoarchitecture that combines isoniazid (INH) and CpG via Fe2+-assisted coordination-driven self-assembly. This strategy enhances antibiotic efficacy and activates the host immune response, offering a potential avenue for improved TB treatment.

Graphical abstract: Metal-coordination-driven self-assembly of DNA nanohybrids for robust intracellular anti-tuberculosis therapy

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Article information

DOI
https://doi.org/10.1039/D4NJ04870A
Article type
Communication
Submitted
11 Nov 2024
Accepted
14 Jan 2025
First published
20 Jan 2025

New J. Chem., 2025,49, 2651-2655

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Metal-coordination-driven self-assembly of DNA nanohybrids for robust intracellular anti-tuberculosis therapy

K. Zhang, H. Sun, X. Gao, T. Liang, X. Gao, H. Song, C. Guan, Z. Sun and J. Zhang, New J. Chem., 2025, 49, 2651 DOI: 10.1039/D4NJ04870A

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